Symposium Short Courses

The Minnesota Chromatography Forum Education Committee presents three short courses in conjunction with the 2018 Spring Symposium. Registration fees include luncheons, refreshments, and course materials. Course attendees can register for the Spring Symposium at reduced rates. Refer to the registration form for details. Short courses include luncheon for 2 days and complimentary 1-year MCF membership. Short course fees do not include registration for Spring Symposium but short course participants may register for the Spring Symposium for a reduced rate!

  • Short courses will be held at the Earle Brown Heritage Center May 8th and the morning of May 9th.
  • Registration deadline: May 1, 2018
  • Registration: $525 before April 15th and $575 from April 15th to May 1st

Optimizing GC Methods and Troubleshooting
Instructed By: Daron Decker

This advanced GC course will explore how to properly develop a method utilizing and applying GC theory, software programs and common sense. Problems will arise and so Troubleshooting will also be examined at length. Analysts should come away with the necessary skills to optimize existing and future methods for faster run times, better resolution, and/or overall robustness.

Course Outline

  • Review of GC Theory
  • Carrier Gas Considerations (Type, Flow rate, EPC)
  • Maximizing Sample Introduction Efficiency
  • Effect of Dimensions (Internal diameter, length, and film thickness) and Effects of Phase Type (Selectivity)
  • Effect of Temperature
  • Maximizing Resolution vs. Fast GC (Method Translation Software)
  • Troubleshooting
  • Conclusions, Discussion, Q&A

Register

Meet the Instructor…

Daron Decker is a Gas Chromatography Applications Specialist for the Chemistries and Supplies Division at Agilent Technologies. Prior to Agilent Daron worked for nearly a decade for J&W Scientific in the area of technical support. Daron has given many seminars, courses and technical papers on GC both domestic and international. Daron’s seminars are well known in the industry for being excellent, informative and entertaining! In May 2003, Daron was awarded the Palmer Award by the MCF. Daron has over 30 years of GC experience and currently lives in the Houston, TX area with his wife of 31 years.



Impurities in Drug Substances and Drug Products—A USP Approach

Instructed By: Shankari Shivaprasad Ph.D. and Ravi Ravichandran Ph.D.

This course integrates ICH Guidance for impurities, relevant USP general chapters, and current industry practices. It also provides insights and practical examples on how to evaluate and manage impurities in drug substances and drug products, and addresses the evaluation of contaminants, adulterants, foreign substances and impurities in drug substances and drug products, and packaging-related extractables and leachables.

Objectives

  • Understand and learn how to apply ICH Guidance Q3A, Q3B and Q3C
  • Comprehend USP General Chapters <232>, <233>, <466>, <467> and <1086>
  • Evaluate contaminants, adulterants, and impurities in drug substances and drug products
  • Review Case Studies for impurities in the development and revision of USP monographs
  • Understand extractables and leachables

Who should attend?

  • Analytical scientists
  • QA/QC
  • Formulators
  • Manufacturing scientists
  • CMC submission and review scientists
  • Regulatory professionals

Register

Dr. Shivaprasad is currently a Senior Scientific Liaison at USP with responsibility for the development of documentary standards (monographs) for small molecular weight medicines intended for the United States Pharmacopeia. She provides support to the Chemical Medicines 1 Expert Committee. Prior to Joining USP, Dr. Shivaprasad was a Principal Scientist at Lancaster Laboratories, Lancaster PA, with responsibility for analytical method development, method validation, documenting work required for GMP compliance, writing/reviewing reports and collaboration with Lancaster Laboratories clients. Shankari played a key role in establishing the mass spectrometry facility for bio-analytical method development and validation of large molecules (biologics), under cGMP regulation. Dr. Shivaprasad also held various positions at other biotech companies in the areas of research and development, mainly on peptide antibiotics and protein aggregation related to Alzheimer’s disease. Dr. Shivaprasad received her Ph.D. in Organic Chemistry from Bangalore University, India, and had subsequent postdoctoral appointments at the University of Zurich, Switzerland, and the University of Tennessee, Knoxville, USA. She has more than 20 publications including review articles in peer-reviewed journals and has also written book chapters.

Dr. Ravichandran is currently a Principal Scientific Liaison at USP with responsibility for the development of documentary standards (monographs) for medicines intended for the United States Pharmacopeia. He provides support to the Chemical Medicines 4 Expert Committee. Prior to Joining USP, Dr. Ravichandran was a Research Scientist at 3M Company, St. Paul, MN, with responsibility for analytical method development, method validation, documenting work required for Drug Delivery Systems, specifically Inhalation aerosol products. Ravi provided support to marketed products. Dr. Ravichandran also held various positions at Roche Diagnostics, Indianapolis, IN in the areas of research and development, mainly for analytical support for self-blood glucose monitoring products and immunodiagnostic products. Dr. Ravichandran received his Ph.D. in Analytical Chemistry from University of Louisville, Louisville, KY. He had subsequent postdoctoral appointment at the University of Georgia, where he worked with Dr. L.B (Buck) Rogers in the area of separations. He has more than 25 publications including review articles in peer-reviewed journals and has also written book chapters.


 


Advanced Topics in Practical HPLC

Instructed By: Dr. David D. Johnson and Dr. Douglas Hanggi

This class is designed to present and review the fundamental bases for liquid chromatographic separations, leading to practical HPLC analyses. In addition to understanding the separation and analysis processes, the class is designed to provide practical understanding of the function, use and maintenance of HPLC and UPLC equipment and columns, method development and transfer, and data analytical approaches.

Course Outline

  • Introduction and review
  • Background theory
  • Overview
  • Understanding the column
  • HPLC detectors
  • Normal-phase mode
  • Reversed-phase mode
  • Ion exchange/Ion Chromatography
  • Size exclusion/Gel permeation chromatography
  • Specialty modes
  • Quantitation methods and concepts
  • HPLC Method Development
  • HPLC performance and troubleshooting
  • Class selected optional topics

Register

Doug Hanggi has been a member of the MCF since the early 1980s, beginning as a member of the Peter Carr group at the University of Minnesota. Since earning his Ph.D. in Analytical Chemistry there in 1987, Doug spent 30 years at 3M, mostly in its Corporate Research Analytical Laboratory, as an HPLC specialist where he used HPLC and HPLC/MS to explore materials ranging from biologicals and organic chemicals and polymers to inorganic ceramics. In addition to his analytical work, Doug also worked closely with technology and product development groups working in areas related to biopurification, nano materials, dental restoratives, and antimicrobial products. Doug is a coinventor on 17 US patents including HPLC adsorbent materials, foams, and dental restoratives. He is now semi-retired and working part time with 3M’s Infection Prevention Division.


 

Cancellation Policy:

Short Course cancellations made by April 8th, 2018, will be issued a full refund less a $25 processing fee for each course cancelled. Short Course cancellations made between April 8th, 2018 and May 1st, 2018, will be issued a 50 % refund of registration fee. Short Course cancellations will not be refunded after May 1, 2018.