Spring Symposium Brochure 2018

39th Annual Spring Symposium
May 8 – 10, 2018
Earle Brown Heritage Center
Minneapolis, MN

Symposium Early Registration Deadline: April 14, 2018
Short Course Early Registration Deadline: April 14, 2018
Abstract Submission Deadline for a Technical Presentation: April 15, 2018
Short Course Final Registration Deadline: May 1, 2018
Symposium Advance Registration Deadline: May 1, 2018
Symposium On-Site Registration: after May 8 – 10, 2018

View a PDF version of the Brochure

View the Technical Program

The Minnesota Chromatography Forum invites you to participate in its 39th Annual Spring Symposium and Short Courses at the Earle Brown Heritage Center in Minneapolis, MN. This year’s program will interest people from all areas of separation science.

KEYNOTE ADDRESS

“Modern Separations in Pharmaceutical Quality: A USP Perspective”

Ravi Ravichandran, Ph.D.

United States Pharmacopeial Convention
– Principal Scientific Liaison
– Chemical Medicines

  • FOCUS SESSIONS
  • GENERAL SESSIONS
  • POSTER SESSIONS
  • SPECIAL TOPICS SESSION
  • INTENSIVE SHORT COURSES
    • “Optimizing GC Methods and Troubleshooting” by Daron Decker
    • “Advanced Topics in Practical HPLC” by David D. Johnson and Douglas Hanggi
    • “Impurities in Drug Substances and Drug Products: A USP Approach” by Shankari Shivaprasad and Ravi Ravichandran

THE UPPER MIDWEST’S LARGEST CHROMATOGRAPHIC INSTRUMENTATION AND SUPPLIES EXHIBITION

On Wednesday afternoon, May 10, you are invited to the Special Topic Session, Vendor Seminars and a concurrent Exhibition of chromatography supplies and instrumentation. Other highlights of Wednesday afternoon are the complimentary Reception in the Exhibit Hall, and the poster session. The Reception, Vendor Seminars, Special Topic Sessions, Equipment Exhibition and Poster Session are free of charge and provide an excellent opportunity to network with fellow chromatographers.

DAILY PROGRAM

Tuesday, May 8, 2018

8:00am- 4:30pm – Concurrent Short Courses

  • “Optimizing GC Methods and Troubleshooting”
  • “Advanced Topics in Practical HPLC”
  • “Impurities in Drug Substances and Drug Products: A USP Approach”

Wednesday, May 9, 2018

8:00am – 12:00pm – Concurrent Short Courses (continued from Tuesday)

12:00pm – 6:00pm – Equipment Exhibition open

1:00pm – 3:00pm – Special Topics Session

2:00pm – 5:00pm – Vendor Seminars

3:30pm – 6:00pm – Reception in the Exhibit Area

1:00pm – 6:00pm – Posters to be displayed

4:00pm – 5:00pm Authors asked to be with their posters

Registration is not required for the Vendor Seminars, Special Topic Sessions, Equipment Exhibition, Reception and Poster Session on Tuesday.

Registration is required to attend Thursday’s sessions.

Thur, May 10, 2018 (Registration required)

7:30am – 3:00pm Registration

10:00am – 4:00pm Vendor Exhibits

10:00am – 3:40pm Posters

8:40am – 10:00am Opening Session

8:40am Welcome

8:45am Announcements

Palmer Award

9:00am Keynote Address

10:00am Refreshments

10:30am – 12:00pm Morning Session

12:00pm Lunch

1:20pm – 3:00pm** Early Afternoon Session

3:00pm – 4:00pm* Refreshments and Prize Drawings in the Exhibit Area

4:00pm – 5:00pm** Late Afternoon Session

5:00pm Annual Business Meeting

* 3:00pm – 3:40pm Authors asked to be at posters

** Tentative times for Afternoon Sessions

KEYNOTE ADDRESS

Thursday Morning, May 10

“Modern Separations in Pharmaceutical Quality: A USP Perspective”

Primary topics:
– USP’s role in Pharmaceutical Quality
– How are Monographs Developed?
– History of Separations in USP Monographs
– Challenges for the Stakeholders

*** KEYNOTE SPEAKER ***

Ravi Ravichandran, Ph.D.

United States Pharmacopeial Convention
– Principal Scientific Liaison
– Chemical Medicines

Dr. Ravichandran has been employed at USP since 2004. In this role he has been supporting the Expert Committees involved in the introduction and revision of documentary standards for psychiatric drugs, inhalation products and radioactive drugs and contrast imaging agents. He provides support to the Chemical Medicines four Expert Committees. Ravi has over 35 years of experience in both industry and government. His industrial experience includes several years in the diagnostics and pharmaceutical industry where he gained experience in analytical methods development for both raw materials and finished product characterization, methods and technology transfer to manufacturing sites, and QC laboratory management. Prior to joining USP, Dr. Ravichandran was a Research Scientist at 3M Company, St. Paul, MN, with responsibility for analytical method development, method validation, documenting work required for Drug Delivery Systems, specifically Inhalation aerosol products. Dr. Ravichandran also held various positions at Roche Diagnostics, Indianapolis, IN in the areas of research and development, mainly for analytical support for self-blood glucose monitoring products and immunodiagnostic products. Dr. Ravichandran received his Ph.D. in Analytical Chemistry from the University of Louisville, Louisville, KY. He had a subsequent postdoctoral appointment at the University of Georgia, where he worked with Dr. L.B (Buck) Rogers in the area of separations. He has more than 25 publications including review articles in peer-reviewed journals and has also written book chapters. In 1999/2000, Ravi served as the President of the Minnesota Chromatography Forum.

SPECIAL TOPICS DISCUSSION

Discussion at 1pm Wednesday Afternoon, May 9
Led by:

  • Daron Decker
  • Ravi Ravichandran

 2018 MCF PALMER AWARDEE 

Professor Douglas Raynie
Department of Chemistry
South Dakota State University
Brookings, South Dakota

SHORT COURSES

Tuesday & Wednesday, May 8 & 9

The Minnesota Chromatography Forum Education Committee presents three short courses in conjunction with the 2018 Spring Symposium. These courses will be conducted all day May 8th and the morning of May 9th at the Earle Brown Heritage Center. The registration deadline is May 1, 2018. Course fees are $525 for early registration before April 15, and $575 from April 15 to May 1. Registration fees include luncheons, refreshments, and course materials. Course attendees can register for the Spring Symposium at reduced rates. Refer to the registration form for details.

Discounts are available for full time students, please contact the events coordinator to authenticate and provide discount information.

COURSE DESCRIPTION

“Impurities in Drug Substances and Drug Products: A USP Approach”
by Shankari Shivaprasad and Ravi Ravichandran

Course Outline

  • Understand and learn how to apply ICH Guidance Q3A, Q3B and Q3C
  • Comprehend USP General Chapters <232>, <233>, <466>, <467> and <1086>
  • Evaluate contaminants, adulterants, and impurities in drug substances and drug products
  • Review Case Studies for impurities in the development and revision of USP monographs
  • Understand extractables and leachables
  • Who should attend?
  • Analytical scientists
  • QA/QC
  • Formulators
  • Manufacturing scientists
  • CMC submission and review scientists
  • Regulatory professionals

Instructors

Dr. Shivaprasad is currently a Senior Scientific Liaison at USP with responsibility for the development of documentary standards (monographs) for small molecular weight medicines intended for the United States Pharmacopeia. She provides support to the Chemical Medicines 1 Expert Committee. Prior to Joining USP, Dr. Shivaprasad was a Principal Scientist at Lancaster Laboratories, Lancaster PA, with responsibility for analytical method development, method validation, documenting work required for GMP compliance, writing/reviewing reports and collaboration with Lancaster Laboratories clients. Shankari played a key role in establishing the mass spectrometry facility for bio-analytical method development and validation of large molecules (biologics), under cGMP regulation. Dr. Shivaprasad also held various positions at other biotech companies in the areas of research and development, mainly on peptide antibiotics and protein aggregation related to Alzheimer’s disease. Dr. Shivaprasad received her Ph.D. in Organic Chemistry from Bangalore University, India, and had subsequent postdoctoral appointments at the University of Zurich, Switzerland, and the University of Tennessee, Knoxville, USA. She has more than 20 publications including review articles in peer-reviewed journals and has also written book chapters.

Dr. Ravichandran is currently a Principal Scientific Liaison at USP with responsibility for the development of documentary standards (monographs) for medicines intended for the United States Pharmacopeia. He provides support to the Chemical Medicines 4 Expert Committee. Prior to Joining USP, Dr. Ravichandran was a Research Scientist at 3M Company, St. Paul, MN, with responsibility for analytical method development, method validation, documenting work required for Drug Delivery Systems, specifically Inhalation aerosol products. Ravi provided support to marketed products. Dr. Ravichandran also held various positions at Roche Diagnostics, Indianapolis, IN in the areas of research and development, mainly for analytical support for self-blood glucose monitoring products and immunodiagnostic products. Dr. Ravichandran received his Ph.D. in Analytical Chemistry from University of Louisville, Louisville, KY. He had subsequent postdoctoral appointment at the University of Georgia, where he worked with Dr. L.B (Buck) Rogers in the area of separations. He has more than 25 publications including review articles in peer-reviewed journals and has also written book chapters.

COURSE DESCRIPTION

“Optimizing GC Methods and Troubleshooting”

by Daron Decker

This advanced GC course will explore how to properly develop a method utilizing and applying GC theory, software programs and common sense. Problems will arise and so Troubleshooting will also be examined at length. Analysts should come away with the necessary skills to optimize existing and future methods for faster run times, better resolution, and/or overall robustness.

Course Outline

  • Review of GC Theory
  • Carrier Gas Considerations (Type, Flow rate, EPC)
  • Maximizing Sample Introduction Efficiency
  • Effect of Dimensions (Internal diameter, length, and film thickness) and
  • Effects of Phase Type (Selectivity)
  • Effect of Temperature
  • Maximizing Resolution vs. Fast GC (Method Translation Software)
  • Troubleshooting
  • Conclusions, Discussion, Q&A

Instructor

Daron Decker is a Gas Chromatography Applications Specialist for the Chemistries and Supplies Division at Agilent Technologies. Prior to Agilent Daron worked for nearly a decade for J&W Scientific in the area of technical support. Daron has given many seminars, courses and technical papers on GC both domestic and international. Daron’s seminars are well known in the industry for being excellent, informative and entertaining! In May 2003, Daron was awarded the Palmer Award by the MCF. Daron has over 30 years of GC experience and currently lives in the Houston, TX area with his wife of 31 years.

COURSE DESCRIPTION

Advanced Topics in Practical HPLC”

by David D. Johnson and Douglas Hanggi

Course Outline

  • Introduction and review
  • Background theory
  • Overview
  • Understanding the column
  • HPLC detectors
  • Normal-phase mode
  • Reversed-phase mode
  • Ion exchange/Ion Chromatography
  • Size exclusion/Gel permeation chromatography
  • Specialty modes
  • Quantitation methods and concepts
  • HPLC Method Development
  • HPLC performance and troubleshooting
  • Class selected optional topics

Instructors

Dr. Doug Hanggi has been a member of the MCF since the early 1980s, beginning as a member of the Peter Carr group at the University of Minnesota. Since earning his Ph.D. in Analytical Chemistry there in 1987, Doug spent 30 years at 3M, mostly in its Corporate Research Analytical Laboratory, as an HPLC specialist where he used HPLC and HPLC/MS to explore materials ranging from biologicals and organic chemicals and polymers to inorganic ceramics. In addition to his analytical work, Doug also worked closely with technology and product development groups working in areas related to biopurification, nano materials, dental restoratives, and antimicrobial products. Doug is a coinventor on 17 US patents including HPLC adsorbent materials, foams, and dental restoratives. He is now semi-retired and working part time with 3M’s Infection Prevention Division.

JOB BOARD

Listings for “Positions Wanted” and “Positions Available” will be posted on the Job Board. Additional information and forms will be available at the Registration Desk.

DIRECTIONS

Directions to the Earle Brown Heritage Center:

         

From the West:

Take I-94 East and I-694 East to Shingle Creek Parkway exit, follow cloverleaf around, turn left onto Shingle Creek Parkway, left at stoplight (Summit Drive North), left again one block at Earle Brown Drive (first turn), follow around to the main entrance on your right.

From the East:

Take I-94 West and I-694 West to Shingle Creek Parkway exit, follow cloverleaf around, turn right onto Shingle Creek Parkway, left at second stoplight (Summit Drive North), left again one block at Earle Brown Drive, follow around to the main entrance on your right.

From the South:

Take I-494 West to Hwy. 100 North, exit at John Martin Drive, at top of exit, cross through intersection 57th Avenue North to John Martin Drive, turn left, continue to first stop sign, turn right onto Earle Brown Drive, continue through next stop sign, watch for main entrance on your left.

From the North:

Take I-35 South to I-694 West, then to Shingle Creek Parkway exit, follow cloverleaf around, turn right onto Shingle Creek Parkway, left at second stoplight (Summit Drive North), left again one block at Earle Brown Drive, follow around to the main entrance on your right.

PARKING – FREE! FREE!! FREE!!!

There is ample free parking at the Earle Brown Heritage Center!

WHAT IS THE MCF?

The Minnesota Chromatography Forum is a scientific society committed to the advancement of chromatography. Since its founding in 1978, the MCF has provided area chromatographers with the opportunity to expand their knowledge in the separation sciences in a variety of ways.

Each year three evening sessions (typically fall, winter, spring) are held with invited speakers ranging from local experts to leading international chromatographers. In addition to the evening meetings, a three day Spring Symposium and Exposition is held in the Minneapolis/St. Paul area.

BE AN MCF VOLUNTEER

MCF events are organized by volunteers from the MCF membership. The MCF needs your active participation to continue to offer a variety of interesting and informative programs. Members are encouraged to sign up for any of the following committees: Education, Membership, Newsletter, or Symposium (Program, Exhibits, Facilities & Publicity). A description of each committee and a sign-up sheet will be provided in the Spring Symposium program. Please become an active member of the Minnesota Chromatography Forum.

2018 MCF SPRING SYMPOSIUM / COURSE / MEMBERSHIP REGISTRATION FORM

MCF MEMBERSHIP ONLY (1-YEAR) $ 25.00

SPRING SYMPOSIUM – Includes luncheon and complimentary 1-year MCF membership.

Spring Symposium (May 10)

Advanced Registration: $125 before April 15 $150 from April 15 to May 1

On-site Registration $170 after May 1

Spring Symposium with course $100 before April 15 $115 from April 15 to May 1

NOTE: Discounts are available for full time students & retirees. Contact events coordinator to authenticate and provide discount.

SHORT COURSE REGISTRATION

Short courses include luncheon for 2 days and complimentary 1-year MCF membership.

Short course fees do not include registration for Spring Symposium (May 10) but short course participants may register for the Spring Symposium for a reduced rate! Deadline for Course Registration is May 1, 2018.

Short Course Registration: $525 before April 15 $575 from April 15 to May 1

Short Course Offerings:

“Optimizing GC Methods and Troubleshooting” by Daron Decker (May 8-9)

Advanced Topics in Practical HPLC” by David Johnson & Douglas Hanggi (May 8-9)

Impurities in Drug Substances and Drug Products: A USP Perspective” by S. Shivaprasad & R. Ravichandran (May 8-9)

Where to Stay:

  • Embassy Suites, Minneapolis North – Brooklyn Center (763-560-2700):

This hotel is connected to the Earle Brown Heritage Center

MCF has reserved a block of rooms at a discounted rate for the Spring Symposium, starting at $159. Reserve your hotel room now at Embassy Suites by Hilton: Minneapolis North-Brooklyn Center. The discounted rate ends April 16th.

Reservations can be made through the MCF online group page or the Embassy Suites website or by phone at 763-560-2700 or 1-800-Embassy. Please use group code “MCF” when reserving a room via phone or through the Embassy Suites website.

  • Country Inn & Suites – Brooklyn Center: (763-561-0900):

This hotel is located at 2550 Freeway Blvd, Brooklyn Center (1.5 miles from the Earle Brown Heritage Center)

MCF has reserved a block of rooms at a discounted rate for the MCF Spring Symposium, starting at $102.

Make reservations as soon as possible, limited space is available.

Participants desiring accommodation can phone 800-8305222, phone the hotel directly at 763-561-0900, or register online.

Let them know you need to make a reservation in the (MN CHROMATOGRAPHY FORUM) block.

Let them know the Group Code: (CROMO).

Event Coordinator:

Jenn Rosen
Phone: 612-990-3924

Minnesota Chromatography Forum
c/o Rosetree Events
201 East Hennepin, Suite 210
Minneapolis, MN 55414